Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming.

ABSTRACT: Heart failure and chronic kidney disease are major causes of morbidity and mortality internationally. Although these dysfunctions are common and frequently coexist, the factors involved in their relationship in cardiorenal regulation are still largely unknown, mainly due to a lack of detailed molecular targets. Here, we found the increased plasma histamine in a preclinical mouse model of severe cardiac dysfunction, that had been cotreated with angiotensin II (Ang II), nephrectomy, and salt (ANS). The ANS mice exhibited impaired renal function accompanied with heart failure, and histamine depletion, by the genetic inactivation of histidine decarboxylase in mice, exacerbated the ANS-induced cardiac and renal abnormalities, including the reduction of left ventricular fractional shortening and

SUBMITTER: Noguchi K 

PROVIDER: S-EPMC7022214 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature