Rules and Exceptions: The Role of Chromosomal ParB in DNA Segregation and Other Cellular Processes.

ABSTRACT: The segregation of newly replicated chromosomes in bacterial cells is a highly coordinated spatiotemporal process. In the majority of bacterial species, a tripartite ParAB-parS system, composed of an ATPase (ParA), a DNA-binding protein (ParB), and its target(s) parS sequence(s), facilitates the initial steps of chromosome partitioning. ParB nucleates around parS(s) located in the vicinity of newly replicated oriCs to form large nucleoprotein complexes, which are subsequently relocated by ParA to distal cellular compartments. In this review, we describe the role of ParB in various processes within bacterial cells, pointing out interspecies differences. We outline recent progress in understanding the ParB nucleoprotein complex formation and its role in DNA segregation, including ori positio

SUBMITTER: Kawalek A 

PROVIDER: S-EPMC7022226 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature