Herpes Simplex Virus 1-Specific CD8⁺ T Cell Priming and Latent Ganglionic Retention Are Shaped by Viral Epitope Promoter Kinetics.

ABSTRACT: Reactivation of herpes simplex virus 1 (HSV-1) from neurons in sensory ganglia such as the trigeminal ganglia (TG) is influenced by virus-specific CD8⁺ T cells that infiltrate the ganglia at the onset of latency and contract to a stable activated tissue-resident memory population. In C57BL/6 mice, half of HSV-specific CD8⁺ T cells (gB-CD8s) recognize one dominant epitope (residues 498 to 505) on glycoprotein B (gB_498-505), while the remainder (non-gB-CD8s) recognize 19 subdominant epitopes from 12 viral proteins. To address how expression by HSV-1 influences the formation and ganglionic retention of CD8⁺ T cell populations, we developed recombinant HSV-1 with the native immunodominant gB epitope disrupted but then expressed ectopically from diffe

SUBMITTER: Treat BR 

PROVIDER: S-EPMC7022356 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature