Pharmacogenomic Characterization in Bipolar Spectrum Disorders.

ABSTRACT: The holistic approach of personalized medicine, merging clinical and molecular characteristics to tailor the diagnostic and therapeutic path to each individual, is steadily spreading in clinical practice. Psychiatric disorders represent one of the most difficult diagnostic challenges, given their frequent mixed nature and intrinsic variability, as in bipolar disorders and depression. Patients misdiagnosed as depressed are often initially prescribed serotonergic antidepressants, a treatment that can exacerbate a previously unrecognized bipolar condition. Thanks to the use of the patient's genomic profile, it is possible to recognize such risk and at the same time characterize specific genetic assets specifically associated with bipolar spectrum disorder, as well as with the individual respo

SUBMITTER: Fortinguerra S 

PROVIDER: S-EPMC7022469 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature