Common Variants in IL-20 Gene are Associated with Subclinical Atherosclerosis, Cardiovascular Risk Factors and IL-20 Levels in the Cohort of the Genetics of Atherosclerotic Disease (GEA) Mexican Study.

ABSTRACT: Inflammation has been involved in the development of atherosclerosis, type 2 diabetes mellitus, insulin resistance, and obesity. Interleukin 20 is a pro-inflammatory cytokine encoded by a polymorphic gene located in chromosome 1. The aim of the study was to evaluate the association of two IL-20 polymorphisms (rs1400986 and rs1518108) with subclinical atherosclerosis (SA), cardiovascular risk factors and IL-20 levels in a cohort of Mexican individuals. The polymorphisms were determined in 274 individuals with SA and 672 controls. Under different models, rs1400986 (OR = 0.51, P_codominant1 = 0.0001; OR = 0.36, P_codominant2 = 0.014; OR = 0.49, P_dominant = 0.0001 and OR = 0.55, P_additive = 0.0001) and rs1518108 (OR =

SUBMITTER: Angeles-Martinez J 

PROVIDER: S-EPMC7022804 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature