Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications.

ABSTRACT: Amorphous calcium phosphate (ACP) has shown significant effects on the biomineralization and promising applications in bio-medicine. However, the limited stability and porosity of ACP material restrict its practical applications. A storage stable highly porous ACP with Brunauer-Emmett-Teller surface area of over 400 m²/g was synthesized by introducing phosphoric acid to a methanol suspension containing amorphous calcium carbonate nanoparticles. Electron microscopy revealed that the porous ACP was constructed with aggregated ACP nanoparticles with dimensions of several nanometers. Large angle X-ray scattering revealed a short-range atomic order of <20 Å in the ACP nanoparticles. The synthesized ACP demonstrated long-term stability and did not crystallize even after storage for ov

SUBMITTER: Sun R 

PROVIDER: S-EPMC7022897 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature