Analysis of Differentially Expressed Genes in Coronary Artery Disease by Integrated Microarray Analysis.

ABSTRACT: Coronary artery disease (CAD) is a major cause of end-stage cardiac disease. Although profound efforts have been made to illuminate the pathogenesis, the molecular mechanisms of CAD remain to be analyzed. To identify the candidate genes in the advancement of CAD, microarray dataset GSE23766 was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were identified, and pathway and gene ontology (GO) enrichment analyses were performed. The protein-protein interaction network was constructed and the module analysis was performed using the Biological General Repository for Interaction Datasets (BioGRID) and Cytoscape. Additionally, target genes-miRNA regulatory network and target genes-TF regulatory network were constructed and analyzed. There were 894

SUBMITTER: Balashanmugam MV 

PROVIDER: S-EPMC7022900 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature