Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala.

ABSTRACT: Oxidative stress, caused by the overproduction of free radicals, leads to the development of many chronic diseases including cancer. Free radicals are known to damage cellular biomolecules like lipids, proteins, and DNA that results in activation of multiple signaling pathways, growth factors, transcription factors, kinases, inflammatory and cell cycle regulatory molecules. Antioxidants, which are classified as exogenous and endogenous, are responsible for the removal of free radicals and consequently the reduction in oxidative stress-mediated diseases. Diet and medicinal herbs are the major source of antioxidants. Triphala, which is a traditional Ayurvedic formulation that has been used for centuries, has been shown to have immense potential to boost antioxidant activity. It scavenges fre

SUBMITTER: Prasad S 

PROVIDER: S-EPMC7022920 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature