Hyaluronate Nanoparticles as a Delivery System to Carry Neuroglobin to the Brain after Stroke.

ABSTRACT: Therapies against stroke can restore the blood supply but cannot prevent the ischemic damage nor stimulate the recovery of the infarcted zone. The neuroglobin protein plays an important role in the neuro-regeneration process after stroke; however, the method for its effective systemic application has not been identified yet, as neuroglobin is unable to pass through the blood-brain barrier. Previously, we developed different types of sodium hyaluronate nanoparticles, which successfully cross the blood-brain barrier after stroke. In this work, these nanoparticles have been used to carry neuroglobin through the bloodstream to the nerve cells in rats submitted to stroke. We have biosynthesized rat-recombinant neuroglobin and determined the formulation of sodium hyaluronate nanoparticles loaded

SUBMITTER: Blanco S 

PROVIDER: S-EPMC7023086 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature