Stencil Printing-A Novel Manufacturing Platform for Orodispersible Discs.

ABSTRACT: Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals. The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to manufacture flexible dosage forms with acceptable mass and content uniformity. Formulation development was supported by physicochemical characterization of the inks and final dosage forms. The printing of haloperidol (HAL) discs was performed using a prototype stencil printer. Ink development comprised of investigations of ink rheology in combination with printability assessment. The results show that stencil printing can be used to manufacture HAL doses in the therapeutic treatment range for 6-17 year-old children. The therapeutic HAL dose was achieved for t

SUBMITTER: Wickstrom H 

PROVIDER: S-EPMC7023198 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature