Stabilisation and Growth of Metastable Form II of Fluconazole in Amorphous Solid Dispersions.

ABSTRACT: The crystallisation of metastable drug polymorphs in polymer matrices has been reported as a successful approach to enhance the solubility of poorly water-soluble drug molecules. This can be achieved using different polymers, drug to polymer ratios and formulation techniques enabling the formation of stable nuclei and subsequent growth of new or metastable drug polymorphs. In this work we elucidated the polymorphism behaviour of a model compound fluconazole (FLU) embedded in solid dispersions with amorphous Soluplus® (SOL) obtained using spray drying and fusion methods. The effect of humidity on the stability of FLU in the obtained dispersions was also evaluated. FLU at a drug content below 40 wt. % stayed amorphous in the dispersions prepared using the fusion method and crystallised exclu

SUBMITTER: Nowak M 

PROVIDER: S-EPMC7023302 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature