Transcriptomic Analysis Reveals the Wound Healing Activity of Mussel Myticin C.

ABSTRACT: Myticin C is the most studied antimicrobial peptide in the marine mussel Mytilusgalloprovincialis. Although it is constitutively expressed in mussel hemocytes and displays antibacterial, antiviral, and chemotactic functions, recent work has suggested that this molecule is mainly activated after tissue injury. Therefore, the main objective of this work was to characterize the hemocytes' transcriptomic response after a myticin C treatment, in order to understand the molecular changes induced by this cytokine-like molecule. The transcriptome analysis revealed the modulation of genes related to cellular movement, such as myosin, transgelin, and calponin-like proteins, in agreement with results of functional assays, where an implication of myticin C in the in vitro activation of hemocytes and m

SUBMITTER: Rey-Campos M 

PROVIDER: S-EPMC7023338 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature