MicroRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy.

ABSTRACT: Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need for the treatment of these patients. BM is a complex process that is regulated by the formation of a metastatic niche. A better understanding of the brain metastatic processes and the crosstalk between cancer cells and brain microenvironment is essential for designing a novel therapeutic approach. In this context, the aberrant expression of miRNA has been shown to be associated with BM. These non-coding RNAs/miRNAs regulate metastasis through modulating the formation of a metastatic niche and metabolic reprogramming via regulation of their target genes. However, the role of miRNA in breast cancer brain metastasis

SUBMITTER: Kanchan RK 

PROVIDER: S-EPMC7023699 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature