The efficacy and safety of pharmacological treatments for lymphangioleiomyomatosis.

ABSTRACT:

Background

Lymphangioleiomyomatosis (LAM) is a rare, low-grade multisystem neoplastic disease. Most LAM patients are at a high risk of losing lung function at an accelerated rate and developing progressive dyspnea. Recently, several studies have reported their experience with pharmacological treatments for LAM. Therefore, we conducted a systematic review and meta-analysis to assess the efficacy and safety of these therapies.

Methods

PubMed (Medline), EMBASE, Cochrane Library, Web of Science and EBSCO Host were searched (until March 31, 2019) for eligible prospective studies regarding LAM patients treated with pharmacological treatments. Random effect models were used for quantitative analysis.

Results

Fourteen prospective studies regarding five pharmacological treatme

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7023761 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature