The modular nature of protein evolution: domain rearrangement rates across eukaryotic life.

ABSTRACT:

Background

Modularity is important for evolutionary innovation. The recombination of existing units to form larger complexes with new functionalities spares the need to create novel elements from scratch. In proteins, this principle can be observed at the level of protein domains, functional subunits which are regularly rearranged to acquire new functions.

Results

In this study we analyse the mechanisms leading to new domain arrangements in five major eukaryotic clades (vertebrates, insects, fungi, monocots and eudicots) at unprecedented depth and breadth. This allows, for the first time, to directly compare rates of rearrangements between different clades and identify both lineage specific and general patterns of evolution in the context of domain rearrangements. We analyse

SUBMITTER: Dohmen E 

PROVIDER: S-EPMC7023805 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature