Immunogenomic pathways associated with cytotoxic lymphocyte infiltration and survival in colorectal cancer.

ABSTRACT: BACKGROUND:Colorectal cancer (CRC) is the second leading cancer killer in the US today and patients with metastatic disease have only a 14% 5-year survival. One of the most impactful recent advances in cancer therapy, immune checkpoint inhibition, has not been shown to be effective for the majority of these patients. In this study, we use The Cancer Genome Atlas (TCGA) and recently developed informatic-based tools to identify targets for immune based therapy in colorectal cancer patients. METHODS:Open access, pre-processed (level 3) mRNA data and clinical data from colorectal patients from the TCGA was downloaded from FireCloud. Using the Microenvironment Cell Populations-Counter method (MCP-Counter), cytotoxic lymphocyte scores were calculated for all patients. Patients were then grouped

SUBMITTER: Shen Y 

PROVIDER: S-EPMC7023815 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature