Salivary epigenetic biomarkers as predictors of emerging childhood obesity.

ABSTRACT:

Background

Epigenetics could facilitate greater understanding of disparities in the emergence of childhood obesity. While blood is a common tissue used in human epigenetic studies, saliva is a promising tissue. Our prior findings in non-obese preschool-aged Hispanic children identified 17 CpG dinucleotides for which differential methylation in saliva at baseline was associated with maternal obesity status. The current study investigated to what extent baseline DNA methylation in salivary samples in these 3-5-year-old Hispanic children predicted the incidence of childhood obesity in a 3-year prospective cohort.

Methods

We examined a subsample (n = 92) of Growing Right Onto Wellness (GROW) trial participants who were randomly selected at baseline, prior to randomization, based

SUBMITTER: Rushing A 

PROVIDER: S-EPMC7023819 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature