Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways.

ABSTRACT: Hydrogen sulfide (H₂S) is an important signaling molecule that provides protective activities in a variety of physiological and pathological processes. Among the different types of H₂S donor compounds, thioamides have attracted attention due to prior conjugation to nonsteroidal anti-inflammatory drugs (NSAIDs) to access H₂S-NSAID hybrids with significantly reduced toxicity, but the mechanism of H₂S release from thioamides remains unclear. Herein, we reported the synthesis and evaluation of a class of thioamide-derived sulfenyl thiocarbamates (SulfenylTCMs) that function as a new class of H₂S donors. These compounds are efficiently activated by cellular thiols to release carbonyl sulfide (COS), which is quickly converted to H

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7023849 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature