Therapeutic Potential of Lebrikizumab in the Treatment of Atopic Dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a chronic, relapsing skin condition with a wide disease spectrum. Moderate-to-severe cases often need systemic treatment. Conventional immunosuppressants have extensive side effect profiles and require close monitoring. In recent decades, there has been increasing interest in developing targeted systemic immunomodulators for AD, as they have been shown to have efficacy for AD as well as favorable safety profiles. Herein, we review the recent data on lebrikizumab, an interleukin (IL)-13 inhibitor, and its potential role in the treatment of AD.

Objective

Review the mechanism of action, and available data on the efficacy and safety of lebrikizumab for the treatment of AD.

Methods

PubMed, Google Scholar, and clinicaltrials.gov searches

SUBMITTER: Loh TY 

PROVIDER: S-EPMC7023853 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature