MicroRNA-146a as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Background and aims

MicroRNAs including miR146a have a regulatory role on the expression of genes and act with binding to 3'-UTR region of the genes. Cyclooxygenase-2 (COX-2) is involved in carcinogenesis as an inflammatory marker, and microRNA-146a (miR-146a) as a negative regulatory factor. We aimed to evaluate miR146a expression as a prognostic or diagnostic biomarker for esophageal squamous cell carcinoma (ESCC) and also an association between miR146a and COX2 expression.

Materials and methods

We quantified the level of miR-146a and COX-2 expression in cancerous and adjacent normal tissue samples obtained from 34 patients with ESCC, using real-time-PCR. Statistical analyses were conducted using one-sample t-test. Receiver-operating characteristic (ROC) curve and K

SUBMITTER: Sadegh Shesh Poli M 

PROVIDER: S-EPMC7023856 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature