HMGA2 Polymorphisms and Hepatoblastoma Susceptibility: A Five-Center Case-Control Study.

ABSTRACT:

Background

Hepatoblastoma is a rare disease. Its etiology remains obscure. No epidemiological reports have assessed the relationship of High Mobility Group A2 (HMGA2) single nucleotide polymorphisms (SNPs) with hepatoblastoma risk. This case-control study leads as a pioneer to explore whether HMGA2 SNPs (rs6581658 A>G, rs8756 A>C, rs968697 T>C) could impact hepatoblastoma risk.

Methods

We acquired samples from 275 hepatoblastoma cases and 1018 controls who visited one of five independent hospitals located in the different regions of China. The genotyping of HMGA2 SNPs was implemented using the PCR-based TaqMan method, and the risk estimates were quantified by odds ratios (ORs) and 95% confidence intervals (CIs).

Results

In the main analysis

SUBMITTER: Li L 

PROVIDER: S-EPMC7023882 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature