Vaginal microbiome diversity and preterm birth: results of a nested case-control study in Peru.

ABSTRACT:

Purpose

Preterm birth (PTB) is a major cause of neonatal mortality. The vaginal microbiome is associated with PTB, but results vary across racial/ethnic populations. Some evidence suggests gestational age affects this association. We investigated these associations in a novel population, conducting a post hoc analysis assessing if associations differed between women swabbed at different gestational ages.

Methods

We compared vaginal microbiomes from women with PTB (n = 25) to a random sample of women with term births (n = 100) among participants in the Pregnancy Outcomes, Maternal and Infant Study, conducted in Lima, Peru. Using DADA2, we identified taxa from 16S DNA sequencing and used Dirichlet multinomial mixture models to group into community state types (CSTs).

Result

SUBMITTER: Blostein F 

PROVIDER: S-EPMC7024011 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature