Accelerometer-measured Physical Activity, Reproductive Hormones, and DNA Methylation.

ABSTRACT:

Introduction/purpose

Limited studies have examined the association of physical activity with reproductive hormones, DNA methylation, and pubertal status among adolescents.

Methods

Among 248 boys and 271 girls, we estimated daily physical activity levels based on 7 d of wrist-worn accelerometer data. We used an isotemporal substitution paradigm and sex-stratified regression models to examine the association of physical activity levels with 1) testosterone, cortisol, progesterone, and androstenedione concentrations; 2) DNA methylation of long interspersed nucleotide (LINE-1) repeats and the genes H19, hydroxysteroid (11-Beta) dehydrogenase 2 (HSD11B2), and peroxisome proliferator-activated receptor alpha (PPARA) from blood leukocytes; and 3) Tanner stages, adjusted for age, BM

SUBMITTER: Wu Y 

PROVIDER: S-EPMC7024035 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature