Antimicrobial Activity of Protein Fraction from Naja ashei Venom Against Staphylococcus epidermidis.

ABSTRACT: One of the key problems of modern infectious disease medicine is the growing number of drug-resistant and multi-drug-resistant bacterial strains. For this reason, many studies are devoted to the search for highly active antimicrobial substances that could be used in therapy against bacterial infections. As it turns out, snake venoms are a rich source of proteins that exert a strong antibacterial effect, and therefore they have become an interesting research material. We analyzed Naja ashei venom for such antibacterial properties, and we found that a specific composition of proteins can act to eliminate individual bacterial cells, as well as the entire biofilm of Staphylococcus epidermidis. In general, we used ion exchange chromatography (IEX) to obtain 10 protein fractions wi

SUBMITTER: Bocian A 

PROVIDER: S-EPMC7024148 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature