Comparative Chemical Profiling and Monacolins Quantification in Red Yeast Rice Dietary Supplements by ¹H-NMR and UHPLC-DAD-MS.

ABSTRACT: Red yeast rice dietary supplements (RYR DS) are largely sold in Western countries for their cholesterol-lowering/regulating effect due to monacolins, mainly monacolin K (MK), which is, in fact, lovastatin, the first statin drug on the market. ¹H-NMR was used as an easy, rapid and accurate method to establish the chemical profiles of 31 RYR DS and to quantify their monacolin contents. Among all the ¹H resonances of the monacolins found in RYR, only those of the ethylenic protons of the hexahydronaphthalenic ring at 5.84 and 5.56 ppm are suitable for quantification because they show no overlap with the matrix signals. The total content in monacolins per capsule or tablet determined in 28 DS (the content in 3 DS being below the limit of quantification of the method, ≈ 0.

SUBMITTER: Hachem R 

PROVIDER: S-EPMC7024183 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature