Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans.

ABSTRACT: Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orang

SUBMITTER: Wang J 

PROVIDER: S-EPMC7024185 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature