New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078.

ABSTRACT: As part of our continuing efforts to discover new bioactive compounds from microbial sources, a reinvestigation of extracts of scaled-up cultures of the marine-derived Streptomyces sp. strain CA-271078 resulted in the isolation and structural elucidation of four new napyradiomycins (1-3, 5). The known napyradiomycin SC (4), whose structural details had not been previously described in detail, and another ten related known compounds (6-15). The structures of the new napyradiomycins were characterized by HRMS and 1D- and 2D-NMR spectroscopies and their relative configurations were established through a combination of molecular modelling with nOe and coupling constants NMR analysis. The absolute configuration of each compound is also proposed based on biosynthetic arguments and the comparison

SUBMITTER: Carretero-Molina D 

PROVIDER: S-EPMC7024253 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature