Rationally Designed Ruthenium Complexes for Breast Cancer Therapy.

ABSTRACT: Since the discovery of the anticancer potential of ruthenium-based complexes, several species were reported as promising candidates for the treatment of breast cancer, which accounts for the greatest number of new cases in women every year worldwide. Among these ruthenium complexes, species containing bioactive ligand(s) have attracted increasing attention due to their potential multitargeting properties, leading to anticancer drug candidates with a broader range of cellular targets/modes of action. This review of the literature aims at providing an overview of the rationally designed ruthenium-based complexes that have been reported to date for which ligands were carefully selected for the treatment of hormone receptor positive breast cancers (estrogen receptor (ER+) or progesterone recep

SUBMITTER: Golbaghi G 

PROVIDER: S-EPMC7024301 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature