Ontology highlight
ABSTRACT:
SUBMITTER: Kong N
PROVIDER: S-EPMC7024563 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Kong Na N Tao Wei W Ling Xiang X Wang Junqing J Xiao Yuling Y Shi Sanjun S Ji Xiaoyuan X Shajii Aram A Gan Silvia Tian ST Kim Na Yoon NY Duda Dan G DG Xie Tian T Farokhzad Omid C OC Shi Jinjun J
Science translational medicine 20191201 523
Loss of function in tumor suppressor genes is commonly associated with the onset/progression of cancer and treatment resistance. The <i>p53</i> tumor suppressor gene, a master regulator of diverse cellular pathways, is frequently altered in various cancers, for example, in ~36% of hepatocellular carcinomas (HCCs) and ~68% of non-small cell lung cancers (NSCLCs). Current methods for restoration of p53 expression, including small molecules and DNA therapies, have yielded progressive success, but e ...[more]