Limitations of 6-minute walk test reference values for spinal muscular atrophy.

ABSTRACT:

Introduction

The 6-minute walk test (6MWT) is a well-established clinical assessment of functional endurance, validated as a measure of walking ability in spinal muscular atrophy (SMA). The current availability of disease-modifying therapies for SMA indicates a growing need for normative reference data to compare SMA patients with healthy controls.

Methods

The literature was searched in two scientific databases. Studies were evaluated and selected based on adherence to American Thoracic Society guidelines for administering the 6MWT. Reference equations from the selected studies were applied to 6MWT data collected from SMA patients to calculate and compare % predicted values.

Results

Three pediatric and six adult studies were selected for comparison. The % predicted va

SUBMITTER: Goodwin AM 

PROVIDER: S-EPMC7024648 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature