Gold nanoparticle clusters for the investigation of therapeutic efficiency against prostate cancer under near-infrared irradiation.

ABSTRACT: Gold particles have been widely used in the treatment of prostate cancer due to their unique optical properties, such as their light-heat conversion in response to near-infrared radiation. Due to well-defined synthesis mechanisms and simple manufacturing methods, gold particles have been fabricated in various sizes and shapes. However, the low photothermal transduction efficiency in their present form is a major obstacle to practical and therapeutic uses of these particles. In the current work, we present a silica-coated gold nanoparticle cluster to address the therapeutic limit of single gold nanoparticles (AuNPs) and use its photothermal effect for treatment against PC-3, a typical prostate cancer. Due to its specific nanostructure, this gold nanocluster showed three times higher phototh

SUBMITTER: Kim J 

PROVIDER: S-EPMC7024685 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature