Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients.

ABSTRACT: BACKGROUND:The Peroxisome proliferator-activated receptor gamma gene (PPARG), encodes a member of the peroxisome-activated receptor subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) which regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta and PPAR-gamma. The protein encoded by this gene is PPAR-gamma which is a regulator of adipocyte differentiation. PPARG-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. AIM:This study aimed to perform insilico analysis to predict the effects that can be imposed by SNPs reported in PPARG gene. METHODOLOGY:This gene was investigated in NCBI database (http://www.ncbi.nlm.nih.gov/) during the year 2016

SUBMITTER: Mustafa HA 

PROVIDER: S-EPMC7024687 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature