Hydrogen sulfide and hepatic lipid metabolism - a critical pairing for liver health.

ABSTRACT: Hydrogen sulfide (H₂ S) is the most recently recognized gasotransmitter, influencing a wide range of physiological processes. As a critical regulator of metabolism, H₂ S has been suggested to be involved in the pathology of many diseases, particularly obesity, diabetes and cardiovascular disorders. Its involvement in liver health has been brought to light more recently, particularly through knockout animal models, which show severe hepatic lipid accumulation upon ablation of H₂ S metabolic pathways. A complex relationship between H₂ S and lipid metabolism in the liver is emerging, which has significant implications for liver disease establishment and/or progression, regardless of the disease-causing agent. In this review, we discuss the critical

SUBMITTER: Loiselle JJ 

PROVIDER: S-EPMC7024709 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature