Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.

ABSTRACT:

Background and purpose

Calcification of heart valves is a frequent pathological finding in chronic kidney disease and in elderly patients. Hydrogen sulfide (H₂ S) may exert anti-calcific actions. Here we investigated H₂ S as an inhibitor of valvular calcification and to identify its targets in the pathogenesis.

Experimental approach

Effects of H₂ S on osteoblastic transdifferentiation of valvular interstitial cells (VIC) isolated from samples of human aortic valves were studied using immunohistochemistry and western blots. We also assessed H2S on valvular calcification in apolipoprotein E-deficient (ApoE^-/- ) mice.

Key results

In human VIC, H₂ S from donor compounds (NaSH, Na₂ S, GYY4137, AP67, and AP72

SUBMITTER: Sikura KE 

PROVIDER: S-EPMC7024713 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature