3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.

ABSTRACT:

Background and purpose

During angiogenesis, quiescent endothelial cells (ECs) are activated by various stimuli to form new blood vessels from pre-existing ones in physiological and pathological conditions. Many research groups have shown that hydrogen sulfide (H₂ S), the newest member of the gasotransmitter family, acts as a proangiogenic factor. To date, very little is known about the regulatory role of 3-mercaptopyruvate sulfurtransferase (3-MST), an important H₂ S-producing enzyme in ECs. The aim of our study was to explore the potential role of 3-MST in human EC bioenergetics, metabolism, and angiogenesis.

Experimental approach

To assess in vitro angiogenic responses, we used EA.hy926 human vascular ECs subjected to shRNA-mediated 3-MST attenuation

SUBMITTER: Abdollahi Govar A 

PROVIDER: S-EPMC7024714 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature