A time-dependent contribution of hippocampal CB₁ , CB₂ and PPARγ receptors to cannabidiol-induced disruption of fear memory consolidation.

ABSTRACT:

Background and purpose

In preclinical studies, cannabidiol (CBD) mitigates fear memories by facilitating their extinction or interfering with their generalization and reconsolidation. The brain regions and mechanisms underlying these effects, and their temporal window, are still poorly understood. Here, we have investigated related questions in the dorsal hippocampus (DH) during contextual fear consolidation.

Experimental approach

Adult male Wistar rats received CBD (10-30 pmol) intra-DH immediately, 1 or 3 hr after fear conditioning. Effects of CBD on consolidation were inferred behaviourally and by analysing expression of the activity-regulated, cytoskeleton-associated (Arc) protein. The contribution of anandamide, CB₁ , CB₂ , 5-HT_1A , A

SUBMITTER: Raymundi AM 

PROVIDER: S-EPMC7024734 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature