Synthesis and biological evaluation of nicotinamide derivatives with a diarylamine-modified scaffold as succinate dehydrogenase inhibitors.

ABSTRACT: Six novel nicotinamide derivatives bearing a diarylamine-modified scaffold with flexible heterocyclic patterns were designed, synthesized, and characterized in detail via Hydrogen nuclear magnetic resonance (¹H-NMR), Carbon nuclear magnetic resonance (¹³C-NMR), and Electrospray ionization mass spectrometry (ESI-MS). Their fungicidal activities and succinate dehydrogenase (SDH) enzymatic inhibitory abilities were evaluated. Preliminary fungicidal bioassay results showed that some of the target compounds exhibited moderate fungicidal activity. Among them, compound 4a showed 40.54% inhibition against Botrytis cinerea fungi. An SDH enzymatic inhibition assay revealed that the IC₅₀ of compound 4b was 3.18 µM. This result indicated tha

SUBMITTER: Yang Z 

PROVIDER: S-EPMC7024744 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature