A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population.

ABSTRACT:

Purpose

The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 polymorphism (c.444C>G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear.

Patients and methods

A retrospective longitudinal analysis was conducted among 352 Japanese subjects. Each type of physical activity was assigned a metabolic equivalent (MET), and the subjects were classified into sedentary, low or high groups using the "METS*T" (METs × hours per week) value of 5 or 21 as a threshold.

Results

Among the PNPLA3 G/G genotype carriers, the high and low METS*T groups had a lower risk of NAFLD than the se

SUBMITTER: Muto N 

PROVIDER: S-EPMC7024805 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature