Levothyroxine Absorption Test to Differentiate Pseudomalabsorption from True Malabsorption.

ABSTRACT:

Background

The levothyroxine absorption test for evaluation of pseudomalabsorption in patients with primary hypothyroid is not standardised. An individual in whom a workup for malabsorption is warranted remains undefined.

Methods

Twenty-five euthyroid, 25 newly diagnosed hypothyroid, 25 treated hypothyroid with normalised TSH, and 25 hypothyroid subjects with elevated TSH despite adequate dose of levothyroxine for more than 6 months, and 10 euthyroid subjects with true malabsorption were administered levothyroxine (10 μg/kg or maximum 600 μg) to study its absorption profile by measuring free T4 level at hourly intervals for 5 h. Results : Free T4 peaked at 3 h with marginal insignificant decline at 4 h in all groups. The increments of free T4 (between baseline

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC7024890 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature