Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.

ABSTRACT:

Introduction

Microstructural abnormalities in white matter (WM) are often reported in Alzheimer's disease (AD). However, it is unclear which brain regions have the strongest WM changes in presymptomatic AD and what biological processes underlie WM abnormality during disease progression.

Methods

We developed a systems biology framework to integrate matched diffusion tensor imaging (DTI), genetic and transcriptomic data to investigate regional vulnerability to AD and identify genetic risk factors and gene subnetworks underlying WM abnormality in AD.

Results

We quantified regional WM abnormality and identified most vulnerable brain regions. A SNP rs2203712 in CELF1 was most significantly associated with several DTI-derived features in the hippocampus, the top ranked brai

SUBMITTER: Horgusluoglu-Moloch E 

PROVIDER: S-EPMC7025138 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature