Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources.

ABSTRACT:

Objective

Real-world data (RWD) are increasingly used for pharmacoepidemiology and regulatory innovation. Our objective was to compare adverse drug event (ADE) rates determined from two RWD sources, electronic health records and administrative claims data, among children treated with drugs for pulmonary hypertension.

Materials and methods

Textual mentions of medications and signs/symptoms that may represent ADEs were identified in clinical notes using natural language processing. Diagnostic codes for the same signs/symptoms were identified in our electronic data warehouse for the patients with textual evidence of taking pulmonary hypertension-targeted drugs. We compared rates of ADEs identified in clinical notes to those identified from diagnostic code data. In addition, we

SUBMITTER: Geva A 

PROVIDER: S-EPMC7025334 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature