How different aspects of motor dysfunction influence day-to-day function in huntington's disease.

ABSTRACT:

Purpose

This study examined the relationships between different aspects of motor dysfunction (chorea, dystonia, rigidity, incoordination, oculomotor dysfunction, dysarthria, and gait difficulties) and functional status in persons with Huntington's disease.

Methods

A total of 527 persons with Huntington's disease completed the Unified Huntington's Disease Rating Scale motor, total functional capacity, and functional assessments.

Results

Confirmatory factor analysis indicated that a 4-factor model provided a better model fit than the existing 5-factor model. Exploratory factor analysis identified the following 4 factors from the motor scale: dystonia, chorea, rigidity, and a general motor factor. Regression indicated that dystonia (β = -0.47 and -0.79) and rigidity (β =

SUBMITTER: Carlozzi NE 

PROVIDER: S-EPMC7025393 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature