C-reactive protein as a potential biomarker for disease progression in dengue: a multi-country observational study.

ABSTRACT:

Background

Dengue infection can cause a wide spectrum of clinical outcomes. The severe clinical manifestations occur sufficiently late in the disease course, during day 4-6 of illness, to allow a window of opportunity for risk stratification. Markers of inflammation may be useful biomarkers. We investigated the value of C-reactive protein (CRP) measured early on illness days 1-3 to predict dengue disease outcome and the difference in CRP levels between dengue and other febrile illnesses (OFI).

Method

We performed a nested case-control study using the clinical data and samples collected from the IDAMS-consortium multi-country study. This was a prospective multi-center observational study that enrolled almost 8000 participants presenting with a dengue-like illness to outpatien

SUBMITTER: Vuong NL 

PROVIDER: S-EPMC7025413 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature