KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer.

ABSTRACT:

Background

KLF16, a member of the Kruppel-like factor (KLF) family, functions in the regulation of dopaminergic transmission, metabolism, and endocrinology. However, the role of KLF16 in prostate cancer (PCa) remains unknown.

Methods

We screened the expression of KLFs in PCa based on bioinformatics analysis. The protein levels of KLF16 in PCa specimens were confirmed by immunohistochemistry. Inhibiting KLF16 by RNA interference with shRNA was used to determine the effects of KLF16 on PCa cell growth in vitro and in vivo. RNA sequencing was used to investigate the signaling regulated by KLF16 in PCa. Bioinformatics analysis was also used to determine the possible correlations of KLF16 and signaling in PCa cohorts.

Results

Bioinformatics analysis showed that KLF16 may b

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7025737 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature