Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography.

ABSTRACT:

Purpose

Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher sensitivity of positron emission tomography (PET) over MRI enables the use of lower concentrations of manganese, potentially expanding the methodology to humans.

Procedures

PET tracers manganese-51 (Mn-51, t_1/2 = 46 min) and manganese-52 (Mn-52, t_1/2 = 5.6 days) were used in this study. The biodistribution of manganese in animals in the brain and other tissues was studied as well as the uptake in the pancreas after glucose stimulation as a f

SUBMITTER: Saar G 

PROVIDER: S-EPMC7025761 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature