Antidepressants for non-specific low back pain.

ABSTRACT:

Background

Antidepressants are commonly used in the management of low-back pain. However, their use is controversial.

Objectives

The aim of this review was to determine whether antidepressants are more effective than placebo for the treatment of non-specific low-back pain.

Search strategy

Randomised controlled trials were identified from MEDLINE and EMBASE (to September 2007), PsycINFO to June 2006, the Cochrane Central Register of Controlled Trials 2006, issue 2, and previous systematic reviews.

Selection criteria

We included randomised controlled trials that compared antidepressant medication and placebo for patients with non-specific low-back pain, and used at least one clinically relevant outcome measure.

Data collection and analysis

Two blinded revi

SUBMITTER: Urquhart DM 

PROVIDER: S-EPMC7025781 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature