Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens.

ABSTRACT: The relationship between antibiotic stewardship and population levels of antibiotic resistance remains unclear. In order to better understand shifts in selective pressure due to stewardship, we use publicly available data to estimate the effect of changes in prescribing on exposures to frequently used antibiotics experienced by potentially pathogenic bacteria that are asymptomatically colonizing the microbiome. We quantify this impact under four hypothetical stewardship strategies. In one scenario, we estimate that elimination of all unnecessary outpatient antibiotic use could avert 6% to 48% (IQR: 17% to 31%) of exposures across pairwise combinations of sixteen common antibiotics and nine bacterial pathogens. All scenarios demonstrate that stewardship interventions, facilitated by changes

SUBMITTER: Tedijanto C 

PROVIDER: S-EPMC7025820 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature