Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.

ABSTRACT: Tubular epithelia are a basic building block of organs and a common site of cancer occurrence^1-4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical parameters that underlie the adoption of abnormal tumour tissue shapes are unknown. Here we show in the pancreas of mice that the morphology of epithelial tumours is determined by the interplay of cytoskeletal changes in transformed cells and the existing tubular geometry. To analyse the morphological changes in tissue architecture during the initiation of cancer, we developed a three-dimensional whole-organ imaging technique that enables tissue analysis at single-cell resolution. Oncogenic transformation of pancreatic ducts led to two types of neoplastic growth

SUBMITTER: Messal HA 

PROVIDER: S-EPMC7025886 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature