The guidance receptor plexin D1 is a mechanosensor in endothelial cells.

ABSTRACT: Shear stress on arteries produced by blood flow is important for vascular development and homeostasis but can also initiate atherosclerosis¹. Endothelial cells that line the vasculature use molecular mechanosensors to directly detect shear stress profiles that will ultimately lead to atheroprotective or atherogenic responses². Plexins are key cell-surface receptors of the semaphorin family of cell-guidance signalling proteins and can regulate cellular patterning by modulating the cytoskeleton and focal adhesion structures^3-5. However, a role for plexin proteins in mechanotransduction has not been examined. Here we show that plexin D1 (PLXND1) has a role in mechanosensation and mechanically induced disease pathogenesis. PLXND1 is required for the response of

SUBMITTER: Mehta V 

PROVIDER: S-EPMC7025890 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature