Effects of cartilage-targeting moieties on nanoparticle biodistribution in healthy and osteoarthritic joints.

ABSTRACT: Understanding intra-articular biodistribution is imperative as candidate osteoarthritis (OA) drugs become increasingly site-specific. Cartilage has been identified as opportunistic for therapeutic intervention, but poses numerous barriers to drug delivery. To facilitate drug delivery to cartilage, nanoscale vehicles have been designed with different features that target the tissue's matrix. However, it is unclear if these targeting strategies are influenced by OA and the associated structural changes that occur in cartilage. The goal of this work was to study the effectiveness of different cartilage-targeting nanomaterials with respect to cartilage localization and retention, and to determine how these outcomes change in OA. To address these questions, a nanoparticle (NP) system was develo

SUBMITTER: Brown SB 

PROVIDER: S-EPMC7025912 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature